教师简介：

一、基本情况

姓     名：郭桂杰

性     别：男

政治面貌：中共党员

职    称：教授

职    务：副院长

研究方向：动物病原感染与防控技术

联系电话：0591-83845697

电子邮箱：guoguijie@fafu.edu.cn

二、受教育经历

2002.09-2006.07  山东农业大学动物科技学院  学士

2006.09-2009.07  山东农业大学动物科技学院  硕士

2009.09-2014.07  中国科学院微生物研究所    博士

三、研究工作经历

2014.07-2015.07  中国科学院微生物研究所  助理研究员

2015.07-2016.04  欧蒙医学诊断（中国）有限公司  医学研究员

2016.04-2017.10  中国科学院微生物研究所  助理研究员

2017.11-2021.04  Mayo Clinic（美国妙佑医疗国际）  博士后

2022.03-至今  福建农林大学动物科学学院  教授

2023.05-至今  福建农林大学动物科学学院  副院长

四、科研项目

1. 国家自然科学基金面上项目  2024-2027  主持

2. 国家级青年人才计划项目  2022-2024  主持

3. 福建农林大学人才引进启动基金  2022-2027  主持

4. 国家自然科学基金青年科学基金  2016-2018  主持

五、承担课程

本科生《专业导论》；研究生《兽医公共卫生》《兽医免疫学进展》《高级动物病毒学》《预防兽医学专题》

六、科研成果

国家级青年人才计划入选者

福建省引进高层次人才（B类）

中国畜牧兽医学会动物传染病学分会理事

中国畜牧兽医学会禽病学分会常务理事

福建省畜牧兽医学会常务理事

七、代表性论文与著作

1. Guijie Guo#, Ming Gao#, Xiaochen Gao, Bibo Zhu, Min Deng, Jinzhou Huang, Xinyi Tu, Wootae Kim, Fei Zhao, Qin Zhou, Shouhai Zhu, Zheming Wu, Yuanliang Yan, Yong Zhang, Xiangyu Zeng, Qian Zhu, Ping Yin, Kuntian Luo, Jie Sun, Min Deng*, and Zhenkun Lou*. Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling. Nature Communications 12(1):2187 (2021). (#共同第一作者，*通讯作者)

2. Guijie Guo#, Ming Gao#, Xiaochen Gao, Bibo Zhu, Jinzhou Huang, Kuntian Luo, Yong Zhang, Jie Sun, Min Deng, and Zhenkun Lou*. SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response. Signal Transduction and Targeted Therapy 6(1):119 (2021).

3. Biao Chen#, Guijie Guo#, Guoqing Wang#, Qianwen Zhu, Lulu Wang, Wenhao Shi, Song Wang, Yuhai Chen, Xiaojuan Chi, Faxin Wen, Mohamed Maarouf, Shile Huang, Zhou Yang, and Ji-Long Chen*. ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus. PLOS Pathogens 20(1):e1011958 (2024).

4. Ming Gao#, Guijie Guo#, Jinzhou Huang, Xiaonan Hou, Hyoungjun Ham, Wootae Kim, Fei Zhao, Min Deng, Xinyi Tu, Qin Zhou, Chao Zhang, Qian Zhu, Jiaqi Liu, Yuanliang Yan, Zhijie Xu, Ping Yin, Kuntian Luo, John Weroha, Min Deng*, Daniel D. Billadeau*, and Zhenkun Lou*. DOCK7 protects against replication stress by promoting RPA stability on chromatin. Nucleic Acids Research49(6):3322-3337 (2021).

5. Ming Gao#, Guijie Guo#, Jinzhou Huang, Jake A Kloeber, Fei Zhao, Min Deng, Xinyi Tu, Wootae Kim, Qin Zhou, Chao Zhang, Ping Yin, Kuntian Luo, and Zhenkun Lou*. USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP. Nature Communications 11(1):5362 (2020).

6. Yingying Li, Shasha Liu, Yuhai Chen, Biao Chen, Meng Xiao, Bincai Yang, Kul Raj Rai, Mohamed Maarouf, Guijie Guo*, and Ji-Long Chen*. Syk facilitates influenza A virus replication by restraining innate immunity at the late stage of viral infection. Journal of Virology 96(7):e0020022 (2022).

7. Yun Ma#, Guijie Guo#, Tingting Li, Faxin Wen, Jianling Yang, Biao Chen, Xuefei Wang, and Ji-Long Chen*. A novel imatinib-upregulated long noncoding RNA plays a critical role in inhibition of tumor growth induced by Abl oncogenes. Molecular Cancer 21(1):5 (2022).

8. Guijie Guo, Qingzheng Kang, Xiaomei Zhu, Qinghuang Chen, Xuefei Wang, Yuhai Chen, Jing Ouyang, Lianfeng Zhang, Huo Tan, Runsheng Chen, Shile Huang, and Ji-Long Chen*. A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA. Oncogene 34(14):1768-1779 (2015).

9. Guijie Guo#, Xiaoxue Qiu#, Song Wang#, Yuhai Chen, Paul B. Rothman, Zixu Wang, Yaoxing Chen, Guoshun Wang, and Ji-Long Chen*. The oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B cell transformation and survival of Pim-deficient cells. Oncogene 29(26):3845-3853 (2010).

10. Guijie Guo, Qingzheng Kang, Qinghuang Chen, Zhilong Chen, Jun Wang, Li Tan, and Ji-Long Chen*. High expression of long noncoding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene. FEBS Letters 588(9):1780-1786 (2014).

11. 郭桂杰, 孙淑红, 崔治中*. J亚群禽白血病病毒蛋鸡分离株SD07LK1全基因组核苷酸序列的比较分析, 微生物学报49(3):400-404 (2009).

12. Fei Zhao#, Wootae Kim#, Huanyao Gao, Chao Liu, Yong Zhang, Yuping Chen, Min Deng, Qin Zhou, Jinzhou Huang, Qi Hu, Shih-Hsun Chen, Somaira Nowsheen, Jake A Kloeber, Bo Qin, Ping Yin, Xinyi Tu, Guijie Guo, Sisi Qin, Chao Zhang, Ming Gao, Kuntian Luo, Yilun Liu, Zhenkun Lou*, and Jian Yuan*. ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection. Nature Cell Biology. 23(8):894-904 (2021).

13. Yong Zhang#, Qifan Yang#, Xiangyu Zeng#, Manxiang Wang#, Shuang Dong#, Bin Yang#, Xinyi Tu, Ting Wei, Wenzhuan Xie, Chao Zhang, Qiang Guo, Jake A Kloeber, Yueyu Cao, Guijie Guo, Qin Zhou, Fei Zhao, Jinzhou Huang, Li Liu, Kai Zhang, Mingwei Wang, Ping Yin, Kuntian Luo, Min Deng, Wootae Kim, Jing Hou, Yu Shi, Qian Zhu, Lifeng Chen, Sheng Hu*, Junqiu Yue*, Guoliang Pi*, and Zhenkun Lou*. MET amplification attenuates lung tumor response to immunotherapy by inhibiting STING. Cancer Discovery 11(11):2726-2737 (2021).

14. Qian Zhu#, Jinzhou Huang#, Hongyang Huang, Huan Li, Peiqiang Yi, Jake A Kloeber, Jian Yuan, Yuping Chen, Min Deng, Kuntian Luo, Ming Gao, Guijie Guo, Xinyi Tu, Ping Yin, Yong Zhang, Jun Su, Jiayi Chen*, and Zhenkun Lou*. RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination. Nature Communications. 12(1):6653 (2021).

15. Jinzhou Huang#, Qin Zhou#, Ming Gao, Somaira Nowsheen, Fei Zhao, Wootae Kim, Qian Zhu, Yusuke Kojima, Ping Yin, Yong Zhang, Guijie Guo, Xinyi Tu, Min Deng, Kuntian Luo, Bo Qin, Yuichi Machida, and Zhenkun Lou*. Tandem deubiquitination and acetylation of SPRTN promotes DNA-Protein crosslink repair and protects against aging. Molecular Cell 79(5):824-835.e5 (2020).

16. Yuanliang Yan#, Zhijie Xu#, Jinzhou Huang, Guijie Guo, Ming Gao, Wootae Kim, Xiangyu Zeng, Jake A Kloeber, Qian Zhu, Fei Zhao, Kuntian Luo, and Zhenkun Lou*. The deubiquitinase USP36 Regulates DNA replication stress and confers therapeutic resistance through PrimPol stabilization. Nucleic Acids Research 48(22):12711-12726 (2020).

17. Yuping Chen#, Jinhuan Wu#, Guang Liang, Guohe Geng, Fei Zhao, Ping Yin, Somaira Nowsheen, Chengming Wu, Yunhui Li, Lei Li, Wootae Kim, Qin Zhou, Jinzhou Huang, Jiaqi Liu, Chao Zhang, Guijie Guo, Min Deng, Xinyi Tu, Xiumei Gao, Zhongmin Liu, Yihan Chen, Zhenkun Lou, Kuntian Luo, and Jian Yuan*. CHK2-FOXK axis promotes transcriptional control of autophagy programs. Science Advances 6(1):eaax5819 (2020).

18. Wootae Kim#, Fei Zhao#, Rentian Wu, Sisi Qin, Somaira Nowsheen, Jinzhou Huang, Qin Zhou, Yuping Chen, Min Deng, Guijie Guo, Kuntian Luo, Zhenkun Lou*, and Jian Yuan*. ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex. Nature Communications 10(1):5304. (2019).

19. Xinda Li, Guijie Guo, Min Lu, Wenjia Chai, Yucen Li, Xiaomei Tong, Jing Li, Xiaojuan Jia, Wenjun Liu, Dandan Qi*, and Xin Ye*. Long noncoding RNA Lnc-MxA inhibits beta interferon transcription by forming RNA-DNA triplexes at its promoter. Journal of Virology 93(21):e00786-19 (2019).

20. Fang Li#, Yuhai Chen#, Zhaoyuan Zhang#, Jing Ouyang, Yi Wang, Ruoxiang Yan, Shile Huang, George Fu Gao, Guijie Guo, and Ji-Long Chen*. Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity. Nucleic Acids Research 43(21):10321-37 (2015).